Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580640 | 0.90 | L3MBTL1 (0.52) | HRH3LMNATAAR1ALDH1A1ALOX15 | |
| SCHEMBL29430412 | 0.81 | — | — | |
| SCHEMBL54892 | 0.81 | — | — | |
| SCHEMBL41191 | 0.81 | L3MBTL1 (0.59) | HRH3LMNATAAR1ALDH1A1ALOX15 | |
| SCHEMBL29830938 | 0.81 | L3MBTL1 (0.59) | HRH3LMNATAAR1ALDH1A1ALOX15 | |
| SCHEMBL764538 | 0.81 | GRM5 (0.49) | HRH3LMNATAAR1ALDH1A1ALOX15 | |
| SCHEMBL15483868 | 0.80 | MAPT (0.59) | HRH3ALDH1A1HRH1APPTDP1 | |
| SCHEMBL13831057 | 0.80 | L3MBTL1 (0.45) | HRH3LMNATAAR1ALDH1A1ALOX15 | |
| Dimethylamine SCHEMBL6366108 | 0.79 | HRH3 (0.59) | HRH3LMNATAAR1ALDH1A1ALOX15 | |
| Iodide SCHEMBL23406241 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2133335-B9 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO LTD (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-8093395-B2 | Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor | OTSUKA CHEMICAL CO., LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| US-8093395-B2 | Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor | OTSUKA CHEMICAL CO., LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| EP-2133335-B1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO LTD (JP) | 2011-09-28 | — | — | EP | disclosed |
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| EP-2133335-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | Otsuka Chemical Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | SGPL1, SMPD1, SPHK1 | HRH3 549/4885LMNA 1776/4885TAAR1 1580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.