Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7636676 | 0.94 | CA2 (0.51) | CA2HDAC6ALDH1A1HPGDNPC1 | |
| SCHEMBL2561003 | 0.93 | CA2 (0.58) | CA2HDAC6MAPTHSD17B10ESR1 | |
| SCHEMBL7641278 | 0.89 | ESR1 (0.60) | CA2HDAC6ESR1ESR2APP | |
| SCHEMBL7642201 | 0.87 | CA2 (0.56) | CA2ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL20312064 | 0.87 | HDAC6 (0.49) | CA2HDAC6ALDH1A1HPGDNPC1 | |
| SCHEMBL1665299 | 0.85 | NPC1 (0.56) | CA2HDAC6ALDH1A1HPGDNPC1 | |
| SCHEMBL31310542 | 0.85 | NPC1 (0.56) | CA2HDAC6ALDH1A1HPGDNPC1 | |
| SCHEMBL21470083 | 0.84 | CA2 (0.53) | CA2HDAC6MAPTHSD17B10ESR1 | |
| SCHEMBL7636669 | 0.84 | HDAC6 (0.50) | CA2HDAC6ALDH1A1HPGDNPC1 | |
| SCHEMBL7642766 | 0.83 | ESR1 (0.65) | CA2HDAC6HSD17B10ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395769-B1 | ACTIVATION ESTROGEN; THERAPY FOR OSTEOPOROSIS, ANTILIPEMIC AGENTS | ELI LILLY AND COMPANY | 2002-05-28 | — | — | US | claimed |
| US-6096781-A | 2-PHENYL-1-BENZOTHIOPHENE DERIVATIVES ARE USEFUL FOR TREATMENT OF OSTEOPOROSIS AND HYPERLIPEMIA | ELI LILLY AND COMPANY (US) | 2000-08-01 | — | — | US | claimed |
| EP-0920862-A1 | 2-Arylbenzo b thiophenes useful for the treatment of estrogen deprivation syndrome | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | claimed |
| WO-1999025707-A1 | 2-ARYLBENZO[b]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | claimed |
| US-6395769-B1 | ACTIVATION ESTROGEN; THERAPY FOR OSTEOPOROSIS, ANTILIPEMIC AGENTS | ELI LILLY AND COMPANY | 2002-05-28 | — | — | US | disclosed |
| US-6096781-A | 2-PHENYL-1-BENZOTHIOPHENE DERIVATIVES ARE USEFUL FOR TREATMENT OF OSTEOPOROSIS AND HYPERLIPEMIA | ELI LILLY AND COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0920862-A1 | 2-Arylbenzo b thiophenes useful for the treatment of estrogen deprivation syndrome | ELI LILLY AND COMPANY (US) | 1999-06-09 | — | — | EP | disclosed |