Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645256 | 1.00 | OPRM1 (0.46) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7645782 | 0.87 | OPRM1 (0.53) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7645785 | 0.87 | OPRM1 (0.53) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7645587 | 0.85 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7645593 | 0.85 | OPRM1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL7649785 | 0.84 | OPRM1 (0.49) | OPRM1OPRD1 | |
| SCHEMBL7649788 | 0.84 | OPRM1 (0.49) | OPRM1OPRD1 | |
| SCHEMBL7644706 | 0.84 | OPRM1 (0.47) | OPRM1OPRD1 | |
| SCHEMBL7644703 | 0.84 | OPRM1 (0.47) | OPRM1OPRD1 | |
| SCHEMBL7647015 | 0.82 | OPRM1 (0.51) | OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479516-B1 | TREATMENT OF PRURITIC DERMATOSES INCLUDING ALLERGIC DERMATITIS AND ATOPY IN ANIMALS AND HUMANS | PFIZER INC | 2002-11-12 | — | — | US | disclosed |
| EP-1072596-A2 | 4-arylpiperidine derivatives for the treatment of pruritus | PFIZER INC. (US) | 2001-01-31 | — | — | EP | disclosed |