⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14585874 | 0.85 | — | — | |
| SCHEMBL31608758 | 0.81 | ALDH1A1 (0.60) | — | |
| SCHEMBL31608761 | 0.79 | ALDH1A1 (0.58) | — | |
| SCHEMBL3359750 | 0.79 | — | — | |
| SCHEMBL31608756 | 0.79 | ALDH1A1 (0.58) | — | |
| SCHEMBL10458964 | 0.79 | — | — | |
| SCHEMBL9509500 | 0.77 | — | — | |
| SCHEMBL1339167 | 0.77 | — | — | |
| SCHEMBL20761935 | 0.77 | SMN1; SMN2 (0.45) | — | |
| SCHEMBL8861970 | 0.76 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372860-B2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372860-B2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2013-02-12 | — | — | US | disclosed |
| US-20100179132-A1 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS, INC. | 2010-07-15 | — | — | US | disclosed |
| US-20100179132-A1 | CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS | PTC THERAPEUTICS, INC. | 2010-07-15 | — | — | US | disclosed |
| US-20100158858-A1 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. | 2010-06-24 | — | — | US | disclosed |
| US-7601840-B2 | Carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| WO-2009074231-A2 | INSECTICIDAL IMINO HETEROCYCLES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070923-A1 | Insecticide iminoheterocycles | Bayer CropScience AG (DE) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008135181-A2 | INSECTICIDAL SUBSTITUTED 2-AMINOINDANES | BAYER CROPSCIENCE AG (DE) | 2008-11-13 | — | — | WO | disclosed |
| EP-1988080-A1 | Insecticidal substituted 2-aminoindanes | Bayer CropScience AG (DE) | 2008-11-05 | — | — | EP | disclosed |
| US-20070281962-A2 | Administering 1,2,3,6-tetrasubstituted pyrido[3,4-b]indoles to inhibit the 5'-untranslated region-dependent translation; anticarcinogenic agents; retinopathy, rheumatoid arthritis, psoriasis, atherosclerosis, obesity, macular degeneration | PCT THERAPEUTICS, INC. (US) | 2007-12-06 | — | — | US | disclosed |