Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743259 | 0.84 | TDP1 (0.49) | CA9MAPTL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL15087904 | 0.84 | LMNA (0.47) | LMNAMAPTL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL8218438 | 0.83 | LMNA (0.55) | CA9LMNAMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL23267707 | 0.82 | SMN1; SMN2 (0.56) | CA9LMNAMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL12121589 | 0.81 | TP53 (0.50) | KDM4ETSHRPPARGPPARA | |
| SCHEMBL17973685 | 0.81 | PTGDR2 (0.51) | CA9LMNAMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL7646661 | 0.78 | HPGD (0.50) | CA9LMNAMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL10047544 | 0.78 | TDP1 (0.49) | MAPTL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5960630 | 0.78 | HTT (0.48) | CA9LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8478888 | 0.77 | PTPN11 (0.51) | MAPTKDM4EALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479520-B1 | REGULATING APOPTOSIS IN HUMAN CELLS WITH COMPOUNDS SUCH AS: 3-CYANO-6-(2-METHOXY-4-METHYLTHIOIPHENYL)-2(1H)-PYRIDINONE | CELL PATHWAYS, INC. | 2002-11-12 | — | — | US | disclosed |
| US-6046216-A | USEFUL TO INHIBIT THE GROWTH OF NEOPLASTIC CELLS. | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0428268-A2 | Pharmaceutical phenylpyridone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-05-22 | — | — | EP | disclosed |