Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.81 |
| ▸ | HTR2C | P28335 | 9/20 | 0.81 |
| ▸ | DRD2 | P14416 | 8/20 | 0.81 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | APOL1 | O14791 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524422 | 0.89 | HTR2A (1.00) | HTR2AHTR2CDRD2CHRNA7KCNH2 | |
| SCHEMBL7645809 | 0.89 | HTR2A (1.00) | HTR2AHTR2CDRD2CHRNA7KCNH2 | |
| SCHEMBL7648046 | 0.88 | HTR2A (1.00) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL7649978 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2KCNH2MPO | |
| SCHEMBL7649032 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2MPO | |
| SCHEMBL10832307 | 0.82 | HTR2A (0.73) | HTR2AHTR2CDRD2CHRNA7MPO | |
| SCHEMBL7646650 | 0.81 | HTR2A (0.79) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL10832216 | 0.81 | HTR2A (0.72) | HTR2AHTR2CDRD2CHRNA7 | |
| SCHEMBL25772732 | 0.78 | HTR2A (0.68) | HTR2AHTR2CDRD2CHRNA7KCNH2 | |
| SCHEMBL7646923 | 0.78 | HTR2A (0.69) | HTR2AHTR2CDRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999011619-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | claimed |
| US-6486153-B1 | Phenylindole derivatives as 5-HT2A receptor ligands | MERCK SHARP & DOHME LTD. | 2002-11-26 | — | — | US | disclosed |
| WO-1999011619-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |