Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 1.00 |
| ▸ | HTR2C | P28335 | 11/20 | 1.00 |
| ▸ | DRD2 | P14416 | 8/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7645809 | 1.00 | HTR2A (1.00) | HTR2AHTR2CDRD2KCNH2CNR1 | |
| SCHEMBL7648046 | 0.99 | HTR2A (1.00) | HTR2AHTR2CDRD2KCNH2CNR1 | |
| SCHEMBL7646263 | 0.89 | HTR2A (0.81) | HTR2AHTR2CDRD2KCNH2CHRNA7 | |
| SCHEMBL7646650 | 0.88 | HTR2A (0.79) | HTR2AHTR2CDRD2KCNH2HDAC1 | |
| SCHEMBL7649096 | 0.86 | HTR2A (0.78) | HTR2AHTR2CDRD2KCNH2CNR1 | |
| SCHEMBL7650562 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2KCNH2HDAC1 | |
| SCHEMBL7648318 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2KCNH2HDAC1 | |
| SCHEMBL7649305 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2HDAC1 | |
| SCHEMBL7649287 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL7651016 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2CNR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999011619-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | claimed |
| WO-1999011619-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |