SCHEMBL7646290

SCHEMBL7646290

CN(CCCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)C=CCC(C)(C)NC(=O)OC(C)(C)C

nearest known ligand 0.72

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 8/20 0.72
CTSK P43235 3/20 0.40
CTSB P07858 1/20 0.40
CTSS P25774 1/20 0.40
TACR1 P25103 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7646281 1.00 GHSR (0.72) GHSRCTSKCTSBCTSSTACR1
SCHEMBL7647155 0.95 GHSR (0.79) GHSRCTSKCTSBCTSSTACR1
SCHEMBL7647157 0.95 GHSR (0.79) GHSRCTSKCTSBCTSSTACR1
SCHEMBL7646316 0.87 GHSR (0.81) GHSRCTSKCTSBCTSS
SCHEMBL7646310 0.87 GHSR (0.81) GHSRCTSKCTSBCTSS
SCHEMBL6659747 0.86 GHSR (0.64) GHSRCTSKCTSBCTSS
SCHEMBL6659036 0.86 GHSR (0.64) GHSRCTSKCTSBCTSS
SCHEMBL7648934 0.85 GHSR (0.75) GHSR
SCHEMBL7648942 0.85 GHSR (0.75) GHSR
SCHEMBL4423447 0.85 GHSR (0.63) GHSRCTSKCTSBCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923539-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2002-06-05 EP disclosed
EP-1184370-A2 Compounds with growth hormone releasing properties NOVO NORDISK A/S (DK) 2002-03-06 EP disclosed
US-6274584-B1 PEPTIDE DERIVATIVES; BIOAVAILABILITY; ENZYME RESISTANCE; MILK AND WOOL PRODUCTION NOVO NORDISK A/S (DK) 2001-08-14 US disclosed
US-6127354-A FOR TREATMENT OF GROWTH DISORDERS OR TO STIMULATE PRODUCTION OF WOOL OR MILK NOVO NORDISK A/S (DK) 2000-10-03 US disclosed
US-5922770-A NOVEL COMPOUNDS THAT STIMULATE THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY NOVO NORDISK A/S (DK) 1999-07-13 US disclosed
EP-0923539-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1999-06-23 EP disclosed
WO-1998003473-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1998-01-29 WO disclosed