Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.46 |
| ▸ | HTR2C | P28335 | 10/20 | 0.46 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27881033 | 0.72 | NOTUM (0.47) | DRD2 | |
| SCHEMBL28487299 | 0.72 | DYRK1A (0.44) | — | |
| SCHEMBL28274604 | 0.70 | HTR2A (0.51) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL27854004 | 0.70 | HTR2A (0.46) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL28794946 | 0.67 | KMT2A (0.54) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL8513030 | 0.64 | GRM1 (0.46) | DRD2 | |
| SCHEMBL3543681 | 0.63 | MAPT (0.34) | — | |
| SCHEMBL8525408 | 0.63 | HTR2A (1.00) | HTR2AHTR2CDRD2KCNH2 | |
| SCHEMBL28637069 | 0.62 | CHRNA7 (0.36) | — | |
| Biphenyl SCHEMBL958819 | 0.62 | G6PC1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479480-B1 | 1H-INDOLE DERIVATIVES BEARING AN OPTIONALLY SUBSTITUTED PHENYL MOIETY AT THE 2-POSITION OF THE INDOLE RING SYSTEM AND A METHYLENE-LINKED HETEROCYCLIC MOIETY AT THE 3-POSITION OF THE INDOLE RING SYSTEM; SCHIZOPHRENIA TREATMENT | MERCK SHARP & DOHME LTD. (GB) | 2002-11-12 | — | — | US | disclosed |
| WO-2000005229-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2000-02-03 | — | — | WO | disclosed |