SCHEMBL7647136

SCHEMBL7647136

COc1ccc2c(c1)NCN2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 2/20 0.49
PDE3A Q14432 2/20 0.49
SNCA P37840 1/20 0.48
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
MAPK1 P28482 2/20 0.44
POLB P06746 1/20 0.44
CA12 O43570 2/20 0.43
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA7 P43166 2/20 0.43
CA9 Q16790 2/20 0.43
CA14 Q9ULX7 2/20 0.43
MAPT P10636 3/20 0.43
KDM4E B2RXH2 2/20 0.43
GFER P55789 2/20 0.43
TSHR P16473 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11698216 0.86 PDE3B (0.49) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL22160843 0.79 LTA4H (0.52) ALDH1A1CA2KDM4E
SCHEMBL31351355 0.76 SNCA (0.63) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL29242101 0.76 SNCA (0.63) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL14222917 0.75 CES1 (0.47) KDM4E
SCHEMBL30570962 0.75 MAPKAPK2 (0.46) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL3350612 0.75 PDE3B (0.55) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL30724416 0.75 PDE3B (0.55) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL29070691 0.75 MAPKAPK2 (0.46) PDE3BPDE3ASNCAMAOAMAOB
SCHEMBL6968312 0.73 PDE3B (0.53) PDE3BPDE3ASNCAMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118142356-A Method for preparing ultrathin metal-organic framework film by steam-assisted in-situ conversion and separation application thereof 中国科学院大连化学物理研究所 2024-06-07 CN claimed
CN-116262207-A Method for electrochemically synthesizing metal-organic framework membrane and application of metal-organic framework membrane in gas separation 中国科学院大连化学物理研究所 2023-06-16 CN claimed
CN-112973456-A Two-dimensional metal organic framework nanosheet film, and preparation method and application thereof 中国科学院大连化学物理研究所 2021-06-18 CN claimed
US-5093132-A Antiulcer benzimidazole derivative with basic alkali metal or alkaline earth metal compound TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-03-03 US claimed
CN-118142356-A Method for preparing ultrathin metal-organic framework film by steam-assisted in-situ conversion and separation application thereof 中国科学院大连化学物理研究所 2024-06-07 CN disclosed
CN-116262207-A Method for electrochemically synthesizing metal-organic framework membrane and application of metal-organic framework membrane in gas separation 中国科学院大连化学物理研究所 2023-06-16 CN disclosed
CN-112973456-B Two-dimensional metal organic framework nanosheet film, and preparation method and application thereof 中国科学院大连化学物理研究所 2022-05-10 CN disclosed
CN-112973456-A Two-dimensional metal organic framework nanosheet film, and preparation method and application thereof 中国科学院大连化学物理研究所 2021-06-18 CN disclosed
EP-1259238-A1 STABLE ACID LABILE BENZIMIDAZOLE PHARMACEUTICAL COMPOSITIONS Deboeck, Arthur M. (US) 2002-11-27 EP disclosed
WO-2001037834-A1 STABLE ACID LABILE BENZIMIDAZOLE PHARMACEUTICAL COMPOSITIONS GALEPHAR PHARMACEUTICAL RESEARCH, INC. (US) 2001-05-31 WO disclosed