Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6330687 | 0.74 | CYP2D6 (0.48) | KDM4EKMT2AAAK1ALDH1A1TDP1 | |
| SCHEMBL23849533 | 0.70 | SLC22A12 (0.48) | KDM4EKMT2AAAK1ALDH1A1CYP2D6 | |
| SCHEMBL8436504 | 0.68 | EGFR (0.47) | AAK1SMN1; SMN2 | |
| SCHEMBL89415 | 0.67 | EGFR (0.41) | KDM4EKMT2ARAB9AHPGDAAK1 | |
| SCHEMBL20591943 | 0.67 | AAK1 (0.47) | KDM4ERAB9AHPGDAAK1ALDH1A1 | |
| SCHEMBL15624074 | 0.66 | MTNR1A (0.48) | KDM4EHPGDAAK1ALDH1A1L3MBTL1 | |
| SCHEMBL7603005 | 0.66 | AAK1 (0.41) | KDM4EAAK1ALDH1A1NOS2SMN1; SMN2 | |
| SCHEMBL6327584 | 0.66 | CYP2D6 (0.54) | KDM4EKMT2AAAK1ALDH1A1CYP2D6 | |
| SCHEMBL23124466 | 0.65 | AAK1 (0.47) | AAK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14820127 | 0.65 | AAK1 (0.57) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263715-A1 | NOVEL PHENYLHETEROALKYLAMINE DERIVATIVES | AstraZeneca AB (SE) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001062714-A1 | NOVEL PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-30 | — | — | WO | disclosed |