Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648236 | 1.00 | OPRM1 (0.52) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7646404 | 0.91 | OPRM1 (0.47) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7646407 | 0.91 | OPRM1 (0.47) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7649297 | 0.91 | OPRM1 (0.48) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7646739 | 0.91 | OPRM1 (0.48) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7646735 | 0.91 | OPRM1 (0.48) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7645632 | 0.91 | OPRM1 (0.46) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7649289 | 0.91 | OPRM1 (0.48) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7645635 | 0.91 | OPRM1 (0.46) | OPRM1OPRK1OPRD1 | |
| SCHEMBL7649640 | 0.90 | OPRM1 (0.46) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479516-B1 | TREATMENT OF PRURITIC DERMATOSES INCLUDING ALLERGIC DERMATITIS AND ATOPY IN ANIMALS AND HUMANS | PFIZER INC | 2002-11-12 | — | — | US | disclosed |
| EP-1072596-A2 | 4-arylpiperidine derivatives for the treatment of pruritus | PFIZER INC. (US) | 2001-01-31 | — | — | EP | disclosed |