Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.45 |
| ▸ | ANPEP | P15144 | 2/20 | 0.45 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558591 | 0.87 | ALB (0.49) | CNR2SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL3718009 | 0.86 | SMN1; SMN2 (0.52) | CNR2SMN1; SMN2MMEHPGDMEN1 | |
| SCHEMBL21314275 | 0.86 | ERAP2 (0.49) | CNR2SMN1; SMN2ERAP1ERAP2LNPEP | |
| SCHEMBL21314310 | 0.86 | ERAP2 (0.49) | CNR2SMN1; SMN2ERAP1ERAP2LNPEP | |
| SCHEMBL14350869 | 0.86 | MME (0.58) | CNR2SMN1; SMN2MMEHPGDMEN1 | |
| SCHEMBL24533878 | 0.85 | MMP2 (0.58) | CNR2HTTALDH1A1 | |
| SCHEMBL24533867 | 0.85 | MMP2 (0.58) | CNR2HTTALDH1A1 | |
| SCHEMBL5721977 | 0.84 | TSHR (0.51) | CNR2SMN1; SMN2MMEHPGDMEN1 | |
| SCHEMBL24183729 | 0.84 | CNR2 (0.49) | CNR2SMN1; SMN2HPGDMEN1HTT | |
| SCHEMBL14441431 | 0.84 | CTSC (0.51) | ERAP1ERAP2LNPEPIL1RN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358978-B1 | FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS (IN THE CASE OF INFLAMMATION), OSTEOARTHRITIS, ASTHMA, CARDIAC INFARCT, ALZHEIMER'S DISEASE, OR ATHEROSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-03-19 | — | — | US | disclosed |