Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DDO | Q99489 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2781653 | 0.82 | ROCK1 (0.37) | NTRK2CYP2C9CYP2C19KDM4EKMT2A | |
| SCHEMBL10875034 | 0.82 | POLB (0.47) | CYP2C19KDM4EKMT2ACYP3A4HCAR2 | |
| SCHEMBL10876070 | 0.81 | HCAR2 (0.46) | ALPLKDM4EALDH1A1HCAR2CASP3 | |
| SCHEMBL7662074 | 0.81 | KMT2A (0.45) | CYP2C9CYP2C19KDM4EKMT2AMEN1 | |
| SCHEMBL10874128 | 0.80 | POLB (0.49) | CYP2C19KDM4EKMT2ACYP3A4HCAR2 | |
| SCHEMBL9525018 | 0.80 | POLB (0.45) | CYP2C19KDM4EKMT2AALDH1A1CYP3A4 | |
| SCHEMBL10873474 | 0.79 | HPGD (0.48) | KDM4EKMT2AMEN1ALDH1A1HCAR2 | |
| SCHEMBL4745639 | 0.78 | ALDH1A1 (0.52) | KDM4EKMT2AMEN1ALDH1A1HCAR2 | |
| SCHEMBL5127047 | 0.77 | CYP2C9 (0.53) | CYP2C9CYP2C19KDM4EKMT2AMEN1 | |
| SCHEMBL7157289 | 0.76 | ALDH1A1 (0.48) | NTRK2KMT2AMEN1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |