Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586630 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586625 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6592230 | 0.68 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6592235 | 0.68 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586372 | 0.67 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6592499 | 0.63 | PDE4D (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2604931 | 0.61 | CYP1A2 (0.61) | CYP1A1CYP1A2CYP1B1TUBB1TUBB4A | |
| SCHEMBL6585375 | 0.61 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5497383 | 0.60 | NFE2L2 (0.66) | PDGFRBPDGFRACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL5497385 | 0.60 | NFE2L2 (0.66) | PDGFRBPDGFRACYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |