SCHEMBL7650508

SCHEMBL7650508

Clc1ccc(-c2ccccc2C(Cl)Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
PTGS2 P35354 2/20 0.44
PTGS1 P23219 1/20 0.44
TSHR P16473 6/20 0.41
HIF1A Q16665 2/20 0.41
SLC6A4 P31645 2/20 0.41
SLC6A3 Q01959 2/20 0.41
KDM4E B2RXH2 2/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
NR1I2 O75469 1/20 0.41
ABCB11 O95342 1/20 0.41
LMNA P02545 1/20 0.41
NR3C1 P04150 1/20 0.41
PGR P06401 1/20 0.41
CYP3A4 P08684 1/20 0.41
ADRA2A P08913 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
MAPT P10636 1/20 0.41
CNR1 P21554 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7563629 0.84 CYP2A6 (0.44) CYP1A2PTGS2PTGS1TSHRLMNA
SCHEMBL1210867 0.84 CYP2A6 (0.48) CYP1A2PTGS2TSHRMAPK1TDP1
Methane SCHEMBL28759107 0.82 CYP2A6 (0.46) CYP1A2PTGS2TSHRMAPK1TDP1
SCHEMBL28245567 0.82 CYP2A6 (0.46) CYP1A2PTGS2TSHRLMNAMAPT
SCHEMBL9908237 0.81 CA12 (0.56) CYP1A2PTGS2PTGS1TSHRSLC6A4
SCHEMBL7644096 0.81 RAB9A (0.42) TSHRKDM4ELMNAMAPTMAPK1
SCHEMBL9862848 0.78 CYP1A2 (0.63) CYP1A2PTGS2PTGS1TSHRSLC6A4
SCHEMBL4058252 0.78 SLC6A4 (0.45) CYP1A2PTGS2PTGS1TSHRSLC6A4
SCHEMBL31376568 0.76 CYP1A2 (0.40) CYP1A2PTGS2PTGS1TSHRSLC6A4
SCHEMBL18045052 0.76 CYP1A2 (0.68) CYP1A2PTGS2PTGS1TSHRSLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001049642-A1 METHOD FOR PRODUCING DIARYLKETONES AND ACID HALIDES TESSENDERLO CHEMIE N.V. (BE) 2001-07-12 WO claimed
WO-2002042246-A1 METHOD FOR THE PREPARATION OF DICHLORODIARYLMETHANES TESSENDERLO CHEMIE N.V. (BE) 2002-05-30 WO disclosed
WO-2001049642-A1 METHOD FOR PRODUCING DIARYLKETONES AND ACID HALIDES TESSENDERLO CHEMIE N.V. (BE) 2001-07-12 WO disclosed