Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.75 |
| ▸ | HTR2C | P28335 | 6/20 | 0.75 |
| ▸ | DRD2 | P14416 | 5/20 | 0.75 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649287 | 0.91 | HTR2A (0.75) | HTR2AHTR2CDRD2TUBB4ATUBB | |
| SCHEMBL7646650 | 0.88 | HTR2A (0.79) | HTR2AHTR2CDRD2ESR1ESR2 | |
| SCHEMBL7645809 | 0.86 | HTR2A (1.00) | HTR2AHTR2CDRD2HDAC1CNR1 | |
| SCHEMBL8524422 | 0.86 | HTR2A (1.00) | HTR2AHTR2CDRD2HDAC1CNR1 | |
| SCHEMBL7648318 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2ESR1ESR2 | |
| SCHEMBL7649032 | 0.86 | HTR2A (0.75) | HTR2AHTR2CDRD2ESR1ESR2 | |
| SCHEMBL7648046 | 0.85 | HTR2A (1.00) | HTR2AHTR2CDRD2HDAC1CNR1 | |
| SCHEMBL7647918 | 0.80 | HTR2A (0.69) | HTR2AHTR2CDRD2TUBB4ATUBB | |
| SCHEMBL7650562 | 0.79 | HTR2A (0.75) | HTR2AHTR2CDRD2TUBB4ATUBB | |
| SCHEMBL7649305 | 0.79 | HTR2A (0.75) | HTR2AHTR2CDRD2TACR1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486153-B1 | Phenylindole derivatives as 5-HT2A receptor ligands | MERCK SHARP & DOHME LTD. | 2002-11-26 | — | — | US | disclosed |