Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 9/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 2/20 | 0.30 |
| ▸ | GABRD | O14764 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878831 | 1.00 | HCAR2 (0.41) | HCAR2ATMKEAP1NFE2L2GFPT1 | |
| SCHEMBL2388631 | 0.82 | GFPT1 (0.43) | HCAR2ATMGFPT1MAPTRAB9A | |
| SCHEMBL27991557 | 0.82 | HCAR2 (0.39) | HCAR2ATMKEAP1NFE2L2GFPT1 | |
| SCHEMBL4353141 | 0.82 | HCAR2 (0.39) | HCAR2ATMKEAP1NFE2L2GFPT1 | |
| SCHEMBL149786 | 0.82 | — | — | |
| Bromide SCHEMBL29244222 | 0.80 | TSHR (0.41) | TSHRLAP3 | |
| Hydrochloric Acid SCHEMBL28480383 | 0.80 | TSHR (0.41) | TSHRLAP3 | |
| SCHEMBL28180758 | 0.79 | ATM (0.45) | HCAR2ATMTSHRMAPTRAB9A | |
| Butane SCHEMBL1034123 | 0.79 | TSHR (0.42) | TSHRLAP3 | |
| SCHEMBL2110683 | 0.77 | TSHR (0.35) | TSHRSLC1A3SLC1A2SLC1A1LAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1235870-C | Novel use of phenyl hetero alkylamine derivatives | ASTRAZENECA AB (SE) | 2006-01-11 | — | — | CN | disclosed |
| CN-1411435-A | Novel use of phenylheteroalkylamine derivatives | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | CN | disclosed |
| US-6479534-B1 | Indoline derivatives and method of treating obesity | VERNALIS RESEARCH LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |