SCHEMBL7651167

SCHEMBL7651167

N[C@H](CO)Cc1c(Cl)cccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.43
AKR1B1 P15121 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.39
SLC6A4 P31645 3/20 0.39
ADRA2A P08913 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 2/20 0.38
MAOA P21397 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
HTR1A P08908 1/20 0.38
CYP2C9 P11712 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
ADRA1D P25100 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP2C19 P33261 1/20 0.38
ADRA1A P35348 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7651165 1.00 TAAR1 (0.43) TAAR1AKR1B1SMN1; SMN2SLC6A4ADRA2A
SCHEMBL2511832 0.81 TAAR1 (0.50) TAAR1AKR1B1SMN1; SMN2SLC6A4ADRA2A
SCHEMBL29168048 0.79 PNMT (0.53) TAAR1SLC6A4CYP3A4CYP2D6LMNA
SCHEMBL8790684 0.78 TAAR1 (0.46) TAAR1AKR1B1SMN1; SMN2SLC6A4ADRA2A
SCHEMBL28108558 0.78 PNMT (0.48) TAAR1SMN1; SMN2SLC6A4CYP3A4CYP2D6
SCHEMBL3128931 0.78 PNMT (0.48) TAAR1SMN1; SMN2SLC6A4CYP3A4CYP2D6
SCHEMBL5181445 0.78 PNMT (0.48) TAAR1SMN1; SMN2SLC6A4CYP3A4CYP2D6
SCHEMBL10325433 0.77 AKR1B1 (0.42) TAAR1AKR1B1SMN1; SMN2SLC6A4ADRA2A
SCHEMBL16054505 0.77 AKR1B1 (0.42) TAAR1AKR1B1SMN1; SMN2SLC6A4ADRA2A
Hydrochloric Acid SCHEMBL17045213 0.76 PNMT (0.47) TAAR1SMN1; SMN2SLC6A4CYP2D6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6489331-B1 A CONDENSED PURINE DERIVATIVE AS AN ACTIVE INGREDIENT AS AN ENHANCER OF INSULIN SECRETION AND A MEDICAMENT FOR THE TREATMENT OF DIABETES KYOWA HAKKO KOGYO CO., LTD. (JP) 2002-12-03 US disclosed
EP-1092435-A1 REMEDIES FOR DIABETES KYOWA HAKKO KOGYO CO., LTD. (JP) 2001-04-18 EP disclosed