Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.60 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28478696 | 0.86 | HPGD (0.76) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL19326905 | 0.85 | HPGD (0.74) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL29508722 | 0.85 | HPGD (0.79) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL5597952 | 0.84 | HPGD (0.73) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL19747579 | 0.83 | HPGD (0.78) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL28729043 | 0.81 | HPGD (1.00) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL3208233 | 0.81 | HPGD (0.67) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL27463741 | 0.81 | HPGD (0.79) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL6005231 | 0.80 | HPGD (0.66) | HPGDALDH1A1KDM4ERCE1HTT | |
| SCHEMBL22972357 | 0.80 | HPGD (0.72) | HPGDALDH1A1KDM4ERCE1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |