Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.76 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.63 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651189 | 0.86 | HPGD (1.00) | HPGDALDH1A1KDM4ERCE1SMN1; SMN2 | |
| SCHEMBL28475160 | 0.81 | NAMPT (0.63) | HPGDALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL14893135 | 0.80 | MTNR1A (0.74) | HPGDALDH1A1MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL1010724 | 0.78 | MTNR1A (1.00) | HPGDMTNR1AMTNR1BCNR1 | |
| SCHEMBL11896371 | 0.78 | MTNR1A (0.77) | HPGDALDH1A1KDM4EMTNR1AMTNR1B | |
| SCHEMBL2546081 | 0.78 | ALDH1A1 (0.68) | HPGDALDH1A1KDM4ERCE1SMN1; SMN2 | |
| SCHEMBL30223440 | 0.78 | ALDH1A1 (0.68) | HPGDALDH1A1KDM4ERCE1SMN1; SMN2 | |
| SCHEMBL169897 | 0.77 | MTNR1A (0.70) | HPGDALDH1A1MTNR1AMTNR1BSMN1; SMN2 | |
| SCHEMBL31267447 | 0.77 | ALDH1A1 (0.68) | HPGDALDH1A1KDM4ERCE1SMN1; SMN2 | |
| SCHEMBL29111414 | 0.77 | MTNR1A (0.65) | HPGDALDH1A1MTNR1AMTNR1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041272-B | 2- (2-chlorphenyl) quinazoline-4 (3H) -ketone derivative and preparation method and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2020-10-30 | — | — | CN | disclosed |
| CN-110041272-A | 2- (2- chlorphenyl) quinazoline -4 (3H) -one analog derivative and its preparation method and application | 中国人民解放军军事科学院军事医学研究院 | 2019-07-23 | — | — | CN | disclosed |