Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.39 |
| ▸ | ITGAV | P06756 | 4/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460054 | 0.80 | GRM8 (0.48) | GRM8GRM4TBXAS1EPHX2ITGB3 | |
| SCHEMBL5051209 | 0.77 | TBXAS1 (0.43) | GRM8GRM4TBXAS1EPHX2ITGB3 | |
| SCHEMBL5054266 | 0.76 | ANPEP (0.46) | GRM8GRM4TBXAS1ANPEPERAP2 | |
| SCHEMBL5053100 | 0.75 | TBXAS1 (0.46) | GRM8GRM4TBXAS1LMNA | |
| SCHEMBL5053015 | 0.74 | GRM8 (0.46) | GRM8GRM4TBXAS1ANPEPERAP2 | |
| SCHEMBL5054578 | 0.74 | GGH (0.40) | GRM8GRM4TBXAS1KCNN4KCNA5 | |
| SCHEMBL5052905 | 0.74 | GRM8 (0.47) | GRM8GRM4TBXAS1ANPEPERAP2 | |
| SCHEMBL5054564 | 0.73 | TBXAS1 (0.47) | GRM8GRM4TBXAS1LMNA | |
| SCHEMBL7649772 | 0.73 | TBXAS1 (0.50) | GRM8GRM4TBXAS1EPHX2ITGB3 | |
| SCHEMBL8457126 | 0.72 | GGH (0.44) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002514184-A | — | — | 2002-05-14 | — | — | JP | claimed |
| EP-1005348-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998013046-A1 | NAALADASE COMPOSITIONS AND METHODS FOR TREATING GLUTAMATE ABNORMALITY AND EFFECTING NEURONAL ACTIVITY IN ANIMALS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-04-02 | — | — | WO | claimed |