Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648268 | 0.85 | TNF (0.53) | TNFLMNA | |
| SCHEMBL7651102 | 0.84 | TNF (0.52) | TNFALDH1A1SMN1; SMN2 | |
| SCHEMBL7650610 | 0.83 | TNF (0.51) | TNFMAPTKDM4EALDH1A1 | |
| SCHEMBL7648481 | 0.83 | MAPT (0.46) | MAPTALDH1A1TDP1ELANECYP1A2 | |
| SCHEMBL7648315 | 0.82 | TNF (0.50) | TNFMAPTKDM4EALDH1A1 | |
| SCHEMBL14266807 | 0.82 | MAPT (0.47) | TNFMAPTKDM4EIRAK4ALDH1A1 | |
| SCHEMBL7649768 | 0.81 | TNF (0.70) | TNFKDM4EALDH1A1 | |
| SCHEMBL7654430 | 0.81 | TNF (0.70) | TNFKDM4EALDH1A1 | |
| SCHEMBL352528 | 0.80 | MAPT (0.51) | TNFMAPTKDM4EIRAK4ALDH1A1 | |
| SCHEMBL7651129 | 0.78 | CA12 (0.51) | MAPTKDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |