Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060056 | 0.86 | GAA (0.50) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL13534290 | 0.82 | MAPT (0.55) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL8672229 | 0.77 | KMT2A (0.45) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL15798719 | 0.75 | KMT2A (0.44) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL25424962 | 0.74 | KMT2A (0.42) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL23240428 | 0.72 | BRD4 (0.49) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL19847432 | 0.72 | ALDH1A1 (0.50) | KMT2AMAPTTDP1BRD4SMN1; SMN2 | |
| SCHEMBL15798471 | 0.70 | KDM4E (0.51) | KMT2ACYP2C9MAPTGAAMEN1 | |
| SCHEMBL28945709 | 0.70 | BRD4 (0.54) | KMT2ACYP2C9MAPTCYP2C19CYP1A2 | |
| SCHEMBL17372112 | 0.67 | GRIN2D (0.42) | KMT2ACYP2C9MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187842-A1 | HUMAN TUMOR NECROSIS FACTOR RECEPTOR TR10 | Human Genome Sciences, Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073321-A1 | HUMAN TUMOR NECROSIS FACTOR RECEPTOR TR10 | HUMAN GENOME SCIENCES, INC. (US) | 2000-12-07 | — | — | WO | disclosed |