SCHEMBL7651861

SCHEMBL7651861

O=C1CN(c2cccc3ccccc23)C(=O)N1CCCn1ccnc1

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FNTA P49354 11/20 0.53
FNTB P49356 11/20 0.53
QPCT Q16769 1/20 0.48
KDM4E B2RXH2 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6977534 0.72 TSHR (0.52) FNTAFNTBQPCTKDM4EL3MBTL1
SCHEMBL11247886 0.69 POLB (0.68) FNTAFNTBQPCTKDM4EL3MBTL1
SCHEMBL10690041 0.69 HEXA (0.57)
SCHEMBL10856878 0.69 ESR1 (0.64) QPCT
SCHEMBL7654184 0.68 FNTA (0.70) FNTAFNTB
SCHEMBL9382272 0.68 POLB (0.52) FNTAFNTBQPCT
SCHEMBL17525566 0.67 QPCT (0.61) QPCTKDM4E
SCHEMBL29062412 0.66 QPCT (0.69) QPCTKDM4EL3MBTL1
SCHEMBL10688300 0.66 HEXA (0.59)
SCHEMBL7424579 0.66 ESR1 (0.61)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6384061-B1 HYDANTOIN COMPOUNDS REPRESENTED BY FORMULA (I) WHICH SHOWS AN INHIBITORY ACTIVITY AGAINST FARNESYL TRANSFERASE, AND THUS CAN BE USED AS AN ANTI-CANCER AGENT, OR PHARMACEUTICALLY ACCEPTABLE SALTS LG CHEMICAL LTD. (KR) 2002-05-07 US claimed
EP-1000036-A1 HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE LG CHEMICAL LIMITED (KR) 2000-05-17 EP claimed
WO-1999005117-A1 HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE LG CHEMICAL LTD. (KR) 1999-02-04 WO claimed
US-6384061-B1 HYDANTOIN COMPOUNDS REPRESENTED BY FORMULA (I) WHICH SHOWS AN INHIBITORY ACTIVITY AGAINST FARNESYL TRANSFERASE, AND THUS CAN BE USED AS AN ANTI-CANCER AGENT, OR PHARMACEUTICALLY ACCEPTABLE SALTS LG CHEMICAL LTD. (KR) 2002-05-07 US disclosed