Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 10/20 | 0.50 |
| ▸ | PLAT | P00750 | 9/20 | 0.50 |
| ▸ | F10 | P00742 | 11/20 | 0.48 |
| ▸ | F2 | P00734 | 10/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 4/20 | 0.48 |
| ▸ | KLK1 | P06870 | 6/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 6/20 | 0.47 |
| ▸ | HPN | P05981 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659146 | 0.91 | PLAU (0.53) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7651995 | 0.87 | PLAU (0.55) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7663117 | 0.83 | F10 (0.56) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7666062 | 0.83 | PLAU (0.61) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7654656 | 0.82 | KLK1 (0.55) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7657064 | 0.82 | F10 (0.49) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7659139 | 0.81 | PLAU (0.58) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7655295 | 0.81 | PLAU (0.58) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7655686 | 0.79 | F2 (0.47) | PLAUPLATF10F2PRSS1 | |
| SCHEMBL7656758 | 0.79 | PLAU (0.57) | PLAUPLATF10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358960-B1 | FOR THERAPY OF INTRAVASCULAR COAGULATION, CORONARY THROMBOSIS, CEREBRAL INFARCTION, CEREBRAL EMBOLISM, TRANSIENT ISCHEMIC ATTACK, CEREBROVASCULAR DISORDERS, PULMONARY VASCULAR DISEASES, DEEP VENOUS THROMBOSIS, ETC. | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| EP-1078917-A1 | AMIDINO DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-02-28 | — | — | EP | disclosed |