Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.57 |
| ▸ | PLAT | P00750 | 4/20 | 0.57 |
| ▸ | F10 | P00742 | 12/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.57 |
| ▸ | F2 | P00734 | 6/20 | 0.53 |
| ▸ | PLG | P00747 | 2/20 | 0.53 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | KLK1 | P06870 | 4/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663117 | 0.90 | F10 (0.56) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7663332 | 0.90 | F10 (0.63) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7660889 | 0.85 | F2 (0.64) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7656744 | 0.85 | PLAU (0.64) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7655826 | 0.84 | F10 (0.57) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7661924 | 0.84 | F10 (0.55) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7656858 | 0.84 | F10 (0.57) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7652184 | 0.84 | F10 (0.52) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7656024 | 0.84 | F10 (0.57) | PLAUPLATF10PRSS1PRSS2 | |
| SCHEMBL7663325 | 0.84 | F10 (0.55) | PLAUPLATF10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358960-B1 | FOR THERAPY OF INTRAVASCULAR COAGULATION, CORONARY THROMBOSIS, CEREBRAL INFARCTION, CEREBRAL EMBOLISM, TRANSIENT ISCHEMIC ATTACK, CEREBROVASCULAR DISORDERS, PULMONARY VASCULAR DISEASES, DEEP VENOUS THROMBOSIS, ETC. | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |