SCHEMBL7652090

SCHEMBL7652090

O=C(O)C1CN(C(=O)c2cccc3ccccc23)CC1CN1CCC(c2ccc(F)cc2)CC1

nearest known ligand 0.70

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 19/20 0.70
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
TP53 P04637 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7654916 0.93 CCR5 (0.68) CCR5
SCHEMBL7649659 0.93 CCR5 (0.67) CCR5KDM4EALDH1A1TP53TSHR
SCHEMBL7656680 0.89 CCR5 (0.63) CCR5ALDH1A1
SCHEMBL7833271 0.89 CCR5 (0.89) CCR5
SCHEMBL7650129 0.89 CCR5 (0.69) CCR5KDM4EALDH1A1TP53TSHR
SCHEMBL7650168 0.88 CCR5 (0.62) CCR5
SCHEMBL7658255 0.88 CCR5 (0.61) CCR5KDM4EALDH1A1TP53TSHR
SCHEMBL7655030 0.88 CCR5 (0.61) CCR5
SCHEMBL7649692 0.88 CCR5 (0.61) CCR5KDM4E
SCHEMBL7653123 0.87 CCR5 (0.60) CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372764-B1 ANTIINFLAMMATORY AGENTS AND AIDS TREATMENT MERCK & CO., INC. 2002-04-16 US claimed
US-6489354-B1 IN PARTICULAR, THESE COMPOUNDS ARE USEFUL AS MODULATORS OF THE CHEMOKINE RECEPTORS CCR-3 AND/OR CCR-5 USEFUL IN THE TREATMENT AND PREVENTION OF ATOPIC CONDITIONS INCLUDING ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, AND ASTHMA MERCK & CO., INC. 2002-12-03 US disclosed
US-6407116-B1 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS TAKEDA CHEMICAL INDUSTRIES, INC. (JP) 2002-06-18 US disclosed
US-6372764-B1 ANTIINFLAMMATORY AGENTS AND AIDS TREATMENT MERCK & CO., INC. 2002-04-16 US disclosed
WO-2000051609-A1 3-ALKYL SUBSTITUTED PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed
WO-2000051610-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed
EP-1026160-A1 NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS Takeda Chemical Industries, Ltd. (JP) 2000-08-09 EP disclosed