SCHEMBL7652217

SCHEMBL7652217

C[SiH](C)OC([C@H]1CN([C@H](CC2CCC2)C(=O)O)C[C@@H]1c1ccccc1)C(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 20/20 0.48
CACNA1F O60840 1/20 0.48
CACNA1D Q01668 1/20 0.48
CACNA1S Q13698 1/20 0.48
CACNA1C Q13936 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7653015 1.00 CCR5 (0.48) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7983082 0.89 CCR5 (0.49) CCR5
SCHEMBL7983088 0.89 CCR5 (0.49) CCR5
SCHEMBL7984976 0.88 CCR5 (0.38) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7984985 0.88 CCR5 (0.38) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7984581 0.87 CCR5 (0.51) CCR5
SCHEMBL7984575 0.87 CCR5 (0.51) CCR5
SCHEMBL7987333 0.81 CCR5 (0.40) CCR5
SCHEMBL7987321 0.81 CCR5 (0.40) CCR5
SCHEMBL7982904 0.81 CCR5 (0.46) CCR5CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6498161-B1 TREATING INFECTION BY HIV; DELAYING OF THE ONSET OF AIDS; ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS OR RHEUMATOID ARTHRITIS MERCK & CO., INC. 2002-12-24 US disclosed
US-6399619-B1 PREVENTION AND TREATMENT OF AIDS AND VIRAL INFECTION BY HIV MERCK & CO., INC. 2002-06-04 US disclosed
US-6248755-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES MERCK & CO., INC. 2001-06-19 US disclosed