Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650324 | 0.86 | MAPT (0.47) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL7647672 | 0.85 | MEN1 (0.42) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL7653796 | 0.82 | MAPT (0.50) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL7649585 | 0.82 | MAPT (0.47) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL7649914 | 0.82 | IGF1R (0.47) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL608163 | 0.82 | MEN1 (0.68) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL7647493 | 0.82 | MAPT (0.49) | KMT2AMEN1RAD52HRH1MAPT | |
| SCHEMBL7651313 | 0.82 | KMT2A (0.44) | KMT2AMEN1RAD52MAPTTP53 | |
| SCHEMBL7649502 | 0.81 | MEN1 (0.47) | KMT2AMEN1RAD52HTR6MAPT | |
| SCHEMBL7654933 | 0.81 | MAPT (0.51) | KMT2AMEN1RAD52MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |