Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651244 | 0.95 | SIGMAR1 (0.44) | MAPTTP53SIGMAR1GPR183FAAH | |
| SCHEMBL7649585 | 0.89 | MAPT (0.47) | MAPTTP53SIGMAR1MEN1RAD52 | |
| SCHEMBL7653796 | 0.89 | MAPT (0.50) | MAPTTP53MEN1RAD52KMT2A | |
| SCHEMBL7647493 | 0.88 | MAPT (0.49) | MAPTTP53MEN1RAD52KMT2A | |
| SCHEMBL7649914 | 0.87 | IGF1R (0.47) | MAPTTP53SIGMAR1MEN1RAD52 | |
| SCHEMBL7650324 | 0.87 | MAPT (0.47) | MAPTTP53MEN1RAD52KMT2A | |
| SCHEMBL7646684 | 0.86 | MAPT (0.48) | MAPTTP53SIGMAR1MEN1RAD52 | |
| SCHEMBL7649669 | 0.84 | KDM4E (0.51) | MAPTTP53MEN1KMT2ALMNA | |
| SCHEMBL7648451 | 0.83 | TP53 (0.42) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7648593 | 0.82 | GPR183 (0.44) | MAPTTP53MEN1RAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-A1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001029028-A1 | 9- (PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-26 | — | — | WO | disclosed |