Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CFTR | P13569 | 5/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2054575 | 0.85 | ALDH1A1 (0.58) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL30033368 | 0.84 | ALDH1A1 (0.57) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL31357589 | 0.81 | CNR2 (0.60) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL1139411 | 0.81 | CFTR (0.77) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL23582257 | 0.81 | CNR2 (0.60) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL13264181 | 0.80 | CNR1 (0.46) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL15456896 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1HSD17B10MAPTTSHR | |
| SCHEMBL9612065 | 0.79 | CNR1 (0.48) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL31292480 | 0.79 | CNR2 (0.48) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL3445900 | 0.79 | CNR1 (0.48) | ALDH1A1CFTRCNR1CNR2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |