Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EDNRB | P24530 | 4/20 | 0.41 |
| ▸ | EDNRA | P25101 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9460647 | 0.83 | HTT (0.47) | HTTEDNRBEDNRAPOLBNR1I2 | |
| SCHEMBL7651729 | 0.79 | EDNRB (0.51) | EDNRBEDNRAPOLBNR1I2KCNE1 | |
| SCHEMBL9723575 | 0.77 | EDNRB (0.47) | HTTEDNRBEDNRAPOLBNR1I2 | |
| SCHEMBL7652517 | 0.74 | HTT (0.51) | HTTPOLBGAANPSR1KMT2A | |
| SCHEMBL9460361 | 0.72 | TDP1 (0.45) | HTTEDNRBEDNRAPOLBNR1I2 | |
| SCHEMBL9357252 | 0.71 | SMN1; SMN2 (0.49) | EDNRBEDNRAPOLBNR1I2KCNE1 | |
| SCHEMBL9460319 | 0.71 | TSHR (0.54) | POLBGAANPSR1KMT2AMEN1 | |
| SCHEMBL15998733 | 0.71 | EDNRB (0.56) | EDNRBEDNRAPOLBNR1I2KCNE1 | |
| SCHEMBL9357632 | 0.70 | EDNRB (0.50) | EDNRBEDNRAPOLBNR1I2KCNE1 | |
| SCHEMBL28376192 | 0.70 | HTT (0.47) | HTTPOLBGAANPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482947-B1 | Substituted (hetero) aryl compounds, process for their preparation, agents containing them and their use as safeners | HOECHST AKTIENGESELLSCHAFT (DE) | 2002-11-19 | — | — | US | claimed |