Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 8/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652587 | 1.00 | TSHR (0.48) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL6476706 | 0.86 | TSHR (0.46) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL6476703 | 0.86 | TSHR (0.46) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL4826149 | 0.81 | ACHE (0.53) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL6065132 | 0.81 | TSHR (0.52) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL6065128 | 0.81 | TSHR (0.52) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL4826151 | 0.81 | ACHE (0.53) | TSHRSMN1; SMN2CA2CA1ACHE | |
| SCHEMBL27783512 | 0.80 | HCAR2 (0.56) | TSHRSMN1; SMN2ATMHCAR2 | |
| SCHEMBL3720872 | 0.76 | ACHE (0.47) | TSHRSMN1; SMN2CA2ACHEBACE1 | |
| SCHEMBL6064447 | 0.75 | TSHR (0.46) | TSHRSMN1; SMN2CA2CA1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6491903-B1 | NARROW MOLECULAR WEIGHT DISTRIBUTION SHELL-CORE POLYMERS HAVING HYDROPHILIC, CROSSLINKED PERMEABLE SHELLS AND HYDROPHOBIC CORES, USED FOR REDUCING BLOOD CHOLESTEROL AND BILE ACID UPTAKE IN INTERSTINES; DRUG DELIVERY | WASHINGTON UNIVERSITY | 2002-12-10 | — | — | US | disclosed |
| US-6383500-B1 | Particles comprising amphiphilic copolymers, having a crosslinked shell domain and an interior core domain, useful for pharmaceutical and other applications | WASHINGTON UNIVERSITY | 2002-05-07 | — | — | US | disclosed |