SCHEMBL765265

SCHEMBL765265

C[C@H]1CC(NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)CN1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 19/20 0.66
KCNH2 Q12809 9/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL744005 1.00 CCR2 (0.66) CCR2KCNH2
SCHEMBL12465469 1.00 CCR2 (0.66) CCR2KCNH2
SCHEMBL14917523 1.00 CCR2 (0.66) CCR2KCNH2
SCHEMBL615384 0.87 CCR2 (0.73) CCR2KCNH2
Hydrochloric Acid SCHEMBL628735 0.85 CCR2 (0.72) CCR2KCNH2
SCHEMBL15721316 0.85 CCR2 (0.47) CCR2KCNH2
SCHEMBL6262434 0.85 CCR2 (0.68) CCR2KCNH2
SCHEMBL3874185 0.83 CCR2 (0.71) CCR2KCNH2
SCHEMBL3874180 0.83 CCR2 (0.71) CCR2KCNH2
Sulfuric Acid SCHEMBL2485177 0.83 CCR2 (0.68) CCR2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2431357-A2 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors Incyte Corporation (US) 2012-03-21 EP disclosed