Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3741626 | 1.00 | CTSK (0.56) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL19064067 | 1.00 | CTSK (0.56) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL2537459 | 1.00 | CTSK (0.56) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL2992126 | 1.00 | CTSK (0.56) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL2534996 | 1.00 | CTSK (0.56) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL29187991 | 0.92 | USP30 (0.49) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL30158823 | 0.92 | USP30 (0.49) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL29187989 | 0.92 | USP30 (0.49) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL30411534 | 0.92 | USP30 (0.49) | CTSKPDE4BUSP30CPB1MEN1 | |
| SCHEMBL23938305 | 0.91 | PDE4B (0.58) | CTSKPDE4BUSP30MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565436-B1 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE CORP (US) | 2012-04-25 | — | — | EP | disclosed |
| EP-2431357-A2 | 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors | Incyte Corporation (US) | 2012-03-21 | — | — | EP | disclosed |