Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661528 | 0.89 | KCNK3 (0.41) | KMT2AMAPK1MEN1SMN1; SMN2USP2 | |
| SCHEMBL7658662 | 0.86 | MAPK1 (0.39) | KMT2AMAPK1MEN1SMN1; SMN2USP2 | |
| SCHEMBL8185021 | 0.84 | MAP3K5 (0.41) | S1PR1KMT2AMAPK1MEN1SMN1; SMN2 | |
| SCHEMBL7651392 | 0.84 | KCNK3 (0.43) | KMT2AMAPK1MEN1L3MBTL1RXFP1 | |
| SCHEMBL7658672 | 0.79 | KMT2A (0.42) | KMT2AMAPK1MEN1SMN1; SMN2USP2 | |
| SCHEMBL7649740 | 0.78 | MAPT (0.39) | KMT2AMAPK1MEN1SMN1; SMN2USP2 | |
| SCHEMBL7799949 | 0.78 | MAP3K5 (0.40) | KMT2AMAPK1MEN1SMN1; SMN2USP2 | |
| SCHEMBL7792108 | 0.77 | RXFP1 (0.41) | L3MBTL1RXFP1KCNK3KCNK9MAPT | |
| SCHEMBL7653797 | 0.76 | HSD17B10 (0.41) | KMT2AMAPK1MEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7791943 | 0.76 | MEN1 (0.42) | KMT2AMEN1RXFP1KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |