Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659713 | 0.84 | NPC1 (0.42) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| SCHEMBL8186096 | 0.84 | ROCK2 (0.46) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| SCHEMBL7658662 | 0.81 | MAPK1 (0.39) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| SCHEMBL7649740 | 0.79 | MAPT (0.39) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| SCHEMBL6806468 | 0.79 | ROCK2 (0.36) | KMT2AMAPK1MEN1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL6810196 | 0.79 | ROCK2 (0.36) | KMT2AMAPK1MEN1SMN1; SMN2NPC1 | |
| SCHEMBL7653002 | 0.79 | S1PR1 (0.41) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| SCHEMBL7661528 | 0.78 | KCNK3 (0.41) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| SCHEMBL8176080 | 0.78 | KMT2A (0.51) | KMT2AMAPK1MEN1USP2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8186121 | 0.77 | KMT2A (0.50) | KMT2AMAPK1MEN1USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |