Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 6/20 | 0.55 |
| ▸ | CASP3 | P42574 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23795235 | 0.94 | CASP3 (0.55) | TLR2CASP3KMT2A | |
| SCHEMBL30844625 | 0.94 | CASP3 (0.55) | TLR2CASP3KMT2A | |
| SCHEMBL23795234 | 0.94 | CASP3 (0.55) | TLR2CASP3KMT2A | |
| SCHEMBL25182286 | 0.88 | CASP3 (0.53) | TLR2CASP3KMT2AMDM2 | |
| SCHEMBL25182612 | 0.88 | CASP3 (0.53) | TLR2CASP3KMT2AMDM2 | |
| SCHEMBL30353581 | 0.85 | CASP3 (0.55) | TLR2CASP3KMT2ATNFMDM2 | |
| SCHEMBL5574418 | 0.85 | TLR2 (0.66) | TLR2CASP3TNFMDM2 | |
| SCHEMBL30517297 | 0.85 | TLR2 (0.66) | TLR2CASP3TNFMDM2 | |
| SCHEMBL16003008 | 0.85 | TLR2 (0.66) | TLR2CASP3TNFMDM2 | |
| SCHEMBL28413990 | 0.85 | CASP3 (0.55) | TLR2CASP3KMT2ATNFMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |