Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 20/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659700 | 0.89 | HTR7 (0.54) | HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL7651805 | 0.86 | HTR7 (0.53) | HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL7654605 | 0.86 | HTR7 (0.61) | HTR7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7652363 | 0.86 | HTR7 (0.61) | HTR7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7653918 | 0.82 | HTR7 (0.51) | HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL6158015 | 0.82 | HTR7 (0.63) | HTR7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7658622 | 0.81 | HTR7 (0.64) | HTR7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL13944373 | 0.81 | HTR7 (0.64) | HTR7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL7653017 | 0.81 | HTR7 (0.58) | HTR7HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL6158276 | 0.81 | HTR7 (0.64) | HTR7HTR2AHTR2CHTR2BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407112-B1 | 2A,3,4,5-TETRAHYDRO-1H-BENZ(CD)INDOL-2-ONE DERIVATIVES; 5-HYDROXYTRYPTAMINE AGONISTS; SLEEP, CIRCADIAN RHYTHYM, BIPOLAR, AND PSYCHOLOGICAL DISORDER TREATMENT | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1081136-A1 | OPTICALLY ACTIVE TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2001-03-07 | — | — | EP | disclosed |