Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.61 |
| ▸ | CA1 | P00915 | 8/20 | 0.61 |
| ▸ | CA2 | P00918 | 8/20 | 0.61 |
| ▸ | CA9 | Q16790 | 8/20 | 0.61 |
| ▸ | CA12 | O43570 | 3/20 | 0.61 |
| ▸ | CA4 | P22748 | 5/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220550 | 0.82 | MAPK14 (0.48) | — | |
| SCHEMBL8765113 | 0.81 | PTGS2 (0.62) | PTGS2CA1CA2CA9CA4 | |
| SCHEMBL6343526 | 0.80 | PTGS2 (0.64) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8317163 | 0.79 | PTGS2 (0.84) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8688958 | 0.79 | PTGS2 (0.64) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL6342793 | 0.77 | PTGS2 (0.76) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL6342214 | 0.76 | PTGS2 (1.00) | PTGS2CA9PTGS1CHRNA7SMN1; SMN2 | |
| SCHEMBL8633382 | 0.75 | PTGS2 (0.65) | PTGS2CA1CA2CA9CA4 | |
| SCHEMBL8981360 | 0.75 | PTGS2 (0.58) | PTGS2CA1CA2CA9CA4 | |
| SCHEMBL19120605 | 0.74 | MEN1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492411-B1 | TREATING ARTHRITIS; REDUCED SIDE EFFECTS | G. D. SEARLE & CO. | 2002-12-10 | — | — | US | disclosed |