Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.70 |
| ▸ | HTR2A | P28223 | 7/20 | 0.52 |
| ▸ | HTR2C | P28335 | 7/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568858 | 0.82 | NOTUM (0.70) | NOTUMHTR2AHTR2CHTR2BKDM4E | |
| SCHEMBL5564127 | 0.78 | NOTUM (0.50) | NOTUMKDM4ESMN1; SMN2 | |
| SCHEMBL5565450 | 0.74 | NOTUM (0.69) | NOTUMKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL26124057 | 0.73 | NOTUM (0.48) | NOTUMHTR2AHTR2CKDM4EMAPT | |
| SCHEMBL5563636 | 0.73 | NOTUM (0.70) | NOTUMHTR2AHTR2CKDM4EMAPT | |
| SCHEMBL5568369 | 0.73 | NOTUM (0.70) | NOTUMKDM4E | |
| SCHEMBL5568816 | 0.73 | NOTUM (0.76) | NOTUM | |
| SCHEMBL27609230 | 0.71 | KDM4E (0.61) | NOTUMKDM4ESMN1; SMN2 | |
| SCHEMBL869312 | 0.71 | GPR119 (0.50) | NOTUMHTR2AHTR2CGPR119 | |
| SCHEMBL2625773 | 0.70 | NOTUM (0.57) | NOTUMHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-1042288-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033801-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1999-07-08 | — | — | WO | disclosed |