Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.63 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.63 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650733 | 0.94 | AGTR1 (0.58) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL7661202 | 0.91 | PPARG (0.62) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL7657851 | 0.87 | AGTR1 (0.59) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL9552170 | 0.85 | AGTR1 (0.64) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL7650695 | 0.85 | AGTR1 (0.55) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL7659945 | 0.85 | AGTR1 (0.55) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL7659922 | 0.85 | AGTR1 (0.55) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL7659476 | 0.85 | AGTR1 (0.55) | AGTR1AGTR2PPARGACHE | |
| SCHEMBL8841641 | 0.84 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL7654063 | 0.82 | AGTR1 (0.54) | AGTR1AGTR2PPARGACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |