Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661169 | 0.88 | POLB (0.35) | LMNAPOLBALDH1A1GAACYP1A2 | |
| SCHEMBL7657909 | 0.86 | HDAC8 (0.41) | LMNAPOLBMAPTRAB9AALDH1A1 | |
| SCHEMBL7657674 | 0.85 | MAPT (0.49) | LMNAPOLBMAPTRAB9AALDH1A1 | |
| SCHEMBL7655281 | 0.79 | POLB (0.50) | LMNAPOLBMAPTRAB9AALDH1A1 | |
| SCHEMBL7658810 | 0.77 | NPC1 (0.37) | LMNAPOLBMAPTRAB9AALDH1A1 | |
| SCHEMBL7658606 | 0.77 | RORC (0.41) | POLBHDAC8 | |
| SCHEMBL7654645 | 0.77 | KIT (0.39) | RAB9ACYP1A2CYP2C19 | |
| SCHEMBL7650280 | 0.76 | MAPT (0.45) | MAPTRAB9AKDM4ENPSR1HDAC8 | |
| SCHEMBL7659468 | 0.76 | MAPT (0.52) | LMNAPOLBMAPTRAB9AALDH1A1 | |
| SCHEMBL7662349 | 0.76 | MAPT (0.34) | POLBMAPTRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | claimed |
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |