Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383648 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL27469426 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| Hydrochloric Acid SCHEMBL382325 | 0.98 | SMN1; SMN2 (0.51) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL9629603 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL9110895 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL9073323 | 0.87 | SMN1; SMN2 (0.68) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL9110900 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL8706009 | 0.87 | SMN1; SMN2 (0.68) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL5972169 | 0.87 | SMN1; SMN2 (0.68) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A | |
| SCHEMBL3404332 | 0.86 | KMT2A (0.50) | SMN1; SMN2HIF1AALDH1A1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1205191-C | Novel acylguanidine derivatives as inhibitors of bone resorption and vitronectin receptor antagonists | EVENTIS PHARMACEUTICALS DEUTSC (DE) | 2005-06-08 | — | — | CN | disclosed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| CN-1284950-A | Novel acylguanidine derivatives as inhibitors of bone resorption and vitronectin receptor antagonists | EVENTIS PHARMACEUTICALS DEUTSC (DE) | 2001-02-21 | — | — | CN | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0751783-B1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC USE OF AMINOACETYLMERCAPTO DERIVATIVES | MERRELL PHARMA INC (US) | 2000-02-02 | — | — | EP | disclosed |
| CN-1218047-A | Novel imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-06-02 | — | — | CN | disclosed |
| CN-1216767-A | Novel 5-membered ring heterocycles, their prepn. their use and pharmaceutical preparations comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-05-19 | — | — | CN | disclosed |
| EP-0751783-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC AMINOACETYLMERCAPTO DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| CN-1134696-A | Substituted 5-membered heterocycles, process for their preparation and their use | CASSELLA FARBWERKE MAINKUR AG (DE) | 1996-10-30 | — | — | CN | disclosed |
| US-5457196-A | Analgesics, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-10-10 | — | — | US | disclosed |
| US-5455242-A | Analgesics, hypotensive or cardiotonic agents, diuretics, antidepressants or suppressors of vascular response after angioplasty | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1995025532-A1 | HYPOCHOLESTEROLEMIC, ANTIATHEROSCLEROTIC AND HYPOTRIGLYCERIDEMIC AMINOACETYLMERCAPTO DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1995-09-28 | — | — | WO | disclosed |
| US-5428158-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0625987-A1 | AMINOACETYLMERCAPTOACETYLAMIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | disclosed |