Bromide

Bromide

SCHEMBL7653956

Br.Br.O=C(O)C1CCCC(C(=O)O)C1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACE P12821 1/20 0.46
TSHR P16473 3/20 0.46
SLC6A1 P30531 2/20 0.46
SLC6A11 P48066 1/20 0.46
LMNA P02545 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
SLC6A13 Q9NSD5 1/20 0.46
ANPEP P15144 1/20 0.46
BTK Q06187 1/20 0.46
GABRR1 P24046 1/20 0.46
EPHX2 P34913 1/20 0.43
GABRP O00591 1/20 0.42
GABRD O14764 1/20 0.42
GABRA1 P14867 1/20 0.42
GABRB1 P18505 1/20 0.42
GABRG2 P18507 1/20 0.42
GABRB3 P28472 1/20 0.42
GABRA5 P31644 1/20 0.42
GABRA3 P34903 1/20 0.42
GABRA2 P47869 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL7786835 1.00 ACE (0.46) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL13868097 0.97 ACE (0.48) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL17041334 0.97 ACE (0.48) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL35887 0.97 ACE (0.48) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL29844 0.97 ACE (0.48) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL2049696 0.97 ACE (0.48) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL35888 0.97 ACE (0.48) ACETSHRSLC6A1SLC6A11LMNA
SCHEMBL20262981 0.94 ACE (0.46) ACETSHRSLC6A1SLC6A11LMNA
Hydrochloric Acid SCHEMBL7641498 0.94 ACE (0.46) ACETSHRSLC6A1SLC6A11LMNA
Ammonia Solution, Strong SCHEMBL21463027 0.94 ACE (0.46) ACETSHRSLC6A1SLC6A11LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1025099-A1 BIS-QUATERNARY AMMONIUM DERIVATIVES AS NEUROMUSCULAR RELAXANTS Gyermek, Laszlo (US) 2000-08-09 EP claimed
WO-1999021854-A1 BIS-QUATERNARY AMMONIUM DERIVATIVES AS NEUROMUSCULAR RELAXANTS NEWLAXANT LLC (US) 1999-05-06 WO claimed
US-6376510-B1 ADMINISTERING A ALKOXY- AND ACYLOXY-SUBSTITUTED ARALKYL AND ARALKENYL BIS QUATERNARY AMMONIUM DERIVATIVES OF CYCLIC ALKANOL DIESTERS TO A HUMAN AS MUSCLE RELAXANTS NEWLAXANT LLC 2002-04-23 US disclosed
US-6274623-B1 DI- OR POLY-ALKOXY-OR ACYLOXY-SUBSTITUTED ARALKYL AND ARAKENYL QUATERNARY AMMONIUM DERIVATIVES OF CYCLIC AMINOALKANOL DIESTERS SUCH AS BIS(N-(3,4-DIPROPIONYLOXY-BENZYL)GRANATANINIUM-3-ALPHA-YL)ADIPATE DIBROMIDE NEWLAXANT LLC 2001-08-14 US disclosed