Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656135 | 0.89 | HRH3 (0.67) | HRH3L3MBTL1HDAC1OPRL1TMEM97 | |
| SCHEMBL7665076 | 0.83 | HRH3 (0.71) | HRH3HDAC1OPRL1ACHEDPP4 | |
| SCHEMBL7657076 | 0.82 | HRH3 (0.76) | HRH3HDAC1OPRL1TMEM97SIGMAR1 | |
| SCHEMBL7655208 | 0.81 | HRH3 (0.74) | HRH3HDAC1OPRL1ACHE | |
| SCHEMBL6734004 | 0.80 | HRH3 (0.67) | HRH3HDAC1OPRL1DPP4 | |
| SCHEMBL7658318 | 0.77 | HRH3 (0.65) | HRH3L3MBTL1DPP4 | |
| SCHEMBL7657546 | 0.76 | HRH3 (0.69) | HRH3HDAC1OPRL1ACHEDPP4 | |
| SCHEMBL7665250 | 0.76 | HRH3 (0.71) | HRH3OPRL1ACHEKDM4EMAPT | |
| SCHEMBL7652819 | 0.76 | HRH3 (0.77) | HRH3HDAC1OPRL1SIGMAR1ACHE | |
| SCHEMBL7655864 | 0.74 | HRH3 (0.72) | HRH3L3MBTL1OPRL1SIGMAR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002085861-A1 | IMIDAZOLIDINE COMPOUNDS AND THEIR USE AS CXCR3 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |
| US-6469002-B1 | COMPOUNDS WHICH MODULATE CHEMOKINE RECEPTOR ACTIVITY AND ARE USEFUL IN TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. | 2002-10-22 | — | — | US | disclosed |