Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 11/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646575 | 0.95 | CYP3A4 (0.46) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1353608 | 0.87 | TP53 (0.43) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL7651305 | 0.83 | HDAC1 (0.47) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL7649688 | 0.83 | HDAC1 (0.49) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL7649858 | 0.83 | HDAC1 (0.49) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL5306363 | 0.83 | CA1 (0.59) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL31203466 | 0.82 | HDAC4 (0.69) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL9776434 | 0.81 | SOAT2 (0.60) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL1005094 | 0.81 | SOAT2 (0.60) | HDAC4HDAC1HDAC7HDAC11HDAC8 | |
| SCHEMBL11365418 | 0.81 | SOAT2 (0.60) | HDAC4HDAC1HDAC7HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002536440-A | — | — | 2002-10-29 | — | — | JP | claimed |
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | claimed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | claimed |
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |