Sugi Predict

Sugi Predict / Targets / SOAT2

SOAT2

Sterol O-acyltransferase 2 · O75908 · SOAT2 on Sugi Atlas →

12,521 patent compounds predicted against SOAT2, 8,504 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL106356 SCHEMBL106356 1.00 14/20
SCHEMBL233526 SCHEMBL233526 0.60 10/20
SCHEMBL231297 SCHEMBL231297 0.52 9/20
SCHEMBL231296 SCHEMBL231296 0.49 9/20
SCHEMBL384252 SCHEMBL384252 1.00 6/20
SCHEMBL384253 SCHEMBL384253 1.00 6/20
SCHEMBL384546 SCHEMBL384546 1.00 5/20
SCHEMBL384547 SCHEMBL384547 1.00 5/20
SCHEMBL405954 SCHEMBL405954 0.82 5/20
SCHEMBL405955 SCHEMBL405955 0.82 5/20
SCHEMBL407013 SCHEMBL407013 0.70 5/20
SCHEMBL407014 SCHEMBL407014 0.70 5/20
SCHEMBL410046 SCHEMBL410046 0.67 5/20
SCHEMBL410047 SCHEMBL410047 0.67 5/20
SCHEMBL406565 SCHEMBL406565 0.65 5/20
SCHEMBL406566 SCHEMBL406566 0.65 5/20
SCHEMBL408027 SCHEMBL408027 0.62 5/20
SCHEMBL408028 SCHEMBL408028 0.62 5/20
SCHEMBL382711 SCHEMBL382711 0.61 5/20
SCHEMBL382712 SCHEMBL382712 0.61 5/20

Clinical trials — most relevant to SOAT2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Omega 3 and Ischemic Stroke; Fish Oil as an Option PHASE4UNKNOWN
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis PHASE2ACTIVE_NOT_RECRUITING
Hereditary Sensory Neuropathy Serine Trial PHASE2UNKNOWN
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
The Effects of Coenzyme A on Serum Lipids in Patients With Hyperlipidemia PHASE2COMPLETED
Choline Effects - Pre-symptomatic AD PHASE1COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease EARLY_PHASE1COMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children nanWITHDRAWN
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism nanCOMPLETED
Epidemiology of Atherosclerosis nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism nanCOMPLETED
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes nanCOMPLETED
HIV Reverse Cholesterol Transport Study nanUNKNOWN
Association of SGLT2 Inhibitors Therapy With Elastographic and Molecular Markers of Liver Injury in Type 2 Diabetes nanCOMPLETED
Gene Expression in Obesity and Insulin Resistance nanCOMPLETED
Genes Involved in Lipid Disorders nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Targeting zDHHC Enzymes to Counteract Alzheimer's Disease nanNOT_YET_RECRUITING
Thermogenic Silencer Regulatory Factors in Humans nanACTIVE_NOT_RECRUITING
De Novo Lipogenesis in Severity of NAFLD nanCOMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study nanCOMPLETED
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients nanUNKNOWN
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED
Effect of SGLT2 Inhibitors on NAFLD in Type 2 Diabetic Patients with Diabetic Nephropathy nanNOT_YET_RECRUITING
Epigenomic and Metabolomic Signatures of APOA2 Gene by Saturated Fat Interaction nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SOAT2 binder may also engage these)

ProteinNameSimilarity
O77759 — 1.000 O77759 →
Q7TQM4 — 1.000 Q7TQM4 →
O88908 — 1.000 O88908 →
Q60457 — 0.982 Q60457 →
O70536 — 0.978 O70536 →
SOAT1 Sterol O-acyltransferase 1 0.976 landscape →
B0BNG2 — 0.976 B0BNG2 →
Q8C3X8 — 0.976 Q8C3X8 →
Q61263 — 0.975 Q61263 →
Q9BZW4 — 0.975 Q9BZW4 →
O77761 — 0.975 O77761 →
A1L1J9 — 0.975 A1L1J9 →
Q9BU23 — 0.974 Q9BU23 →
Q7TQ65 — 0.973 Q7TQ65 →
O77760 — 0.973 O77760 →
Q49LS7 — 0.973 Q49LS7 →
Q658P3 — 0.973 Q658P3 →
Q8R1J1 — 0.973 Q8R1J1 →
Q9HCP6 — 0.972 Q9HCP6 →
A0A8C2M425 — 0.971 A0A8C2M425 →
Q8IUH8 — 0.971 Q8IUH8 →
Q5KR61 — 0.971 Q5KR61 →
SLC34A1 Sodium-dependent phosphate transport protein 2A 0.971 landscape →
O97704 — 0.971 O97704 →
Q4VV71 — 0.971 Q4VV71 →
Q9D1G3 — 0.970 Q9D1G3 →
Q8VC65 — 0.970 Q8VC65 →
A1L504 — 0.970 A1L504 →
Q496Z4 — 0.970 Q496Z4 →
Q643R3 — 0.970 Q643R3 →