Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.48 |
| ▸ | TP53 | P04637 | 11/20 | 0.48 |
| ▸ | LMNA | P02545 | 10/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.47 |
| ▸ | RB1 | P06400 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665951 | 0.91 | MAPT (0.56) | MAPTTP53LMNARB1HTR6 | |
| SCHEMBL7661635 | 0.91 | MAPT (0.49) | MAPTTP53LMNAHTR6POLB | |
| SCHEMBL7663571 | 0.91 | MAPT (0.49) | MAPTTP53LMNAHTR6POLB | |
| SCHEMBL7653840 | 0.90 | MAPT (0.48) | MAPTTP53LMNARB1HTR6 | |
| SCHEMBL7654336 | 0.83 | HTR1F (0.68) | MAPTTP53LMNAHTR1FHTR6 | |
| SCHEMBL7663838 | 0.82 | HTR1F (0.70) | MAPTLMNAHTR1FHTR1AHTR7 | |
| Bromide SCHEMBL7664575 | 0.81 | HTR1F (0.69) | MAPTLMNAHTR1FHTR1AHTR7 | |
| SCHEMBL7659301 | 0.79 | HTR1F (0.54) | HTR1FHTR1AHTR7 | |
| Oxalic Acid SCHEMBL7653789 | 0.79 | HTR1F (0.66) | MAPTLMNAHTR1FHTR1AHTR7 | |
| SCHEMBL7664557 | 0.78 | HTR1F (0.59) | LMNAHTR1FRB1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380201-B1 | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists | ELI LILLY AND COMPANY | 2002-04-30 | — | — | US | disclosed |
| EP-0749962-B1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | LILLY CO ELI (US) | 2000-11-02 | — | — | EP | disclosed |
| US-5962473-A | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5814653-A | SUMATRIPTAN FOR RELIEF OF MIGRAINE PAIN AND OTHER DISORDERS ASSOCIATED WITH PEPTIDE EXTRAVASATION DIE TO STUMULATION OF THE TRIGEMINAL GANGLIA; 5-HT 1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832650-A2 | Use of serotonin 5-HT1F agonists for the prevention of migraine | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0824917-A2 | Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0749962-A1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |